Differential Diagnosis Of Sickle Cell Disease - 1361 Words

What is your list of differential diagnoses in this case and explain how each of these fits with the case patient as described above. Be sure to list at least four (4) pertinent differential diagnoses. Indicate which of these you would select as the most likely diagnosis and explain why. 1) Sickle Cell Disease (SCD) (Sickle Cell Crisis): Sickle cell disease is a hereditary disease. The majority of individuals affected by SCD are those of African descent (Yawn John-Sowah, 2015). SCD develops hereditarily by an individual being homozygous for sickle hemoglobin (HbSS) (Yawn John-Sowah, 2015). Individuals will also have another abnormal hemoglobin gene, such as HbSC (Yawn John-Sowah, 2015). The red blood cells (RBCs) in SCD lose oxygen and become sickled (Yawn John-Sowah, 2015). The RBCs loose flexibility and shape; sickled cells have been described as having a crescent moon shape (Yawn John-Sowah, 2015). Organ and tissue damage is due to the sickled RBCs (Rees Gibson, 2011). Without flexibility, the sickled cells cause vaso-occlusions which lead to tissue infarction and inflammation (Rees Gibson, 2011). Vasoocclusive crisis (VOC) is a common complication of SCD that will be sudden and severe causing severe pain (Yawn John-Sowah, 2015). Individuals must be monitored for infection, pain, renal failure, cerebrovascular disease, and acute chest syndrome (Rees Gibson, 2011). Individuals with SCD are at a high risk for stroke (Yawn John-Sowah, 2015).Show MoreRelatedA Study On Alyscia And Devon Essay1131 Words   |  5 Pagespresented with an enlarged spleen. Pre-screening indicates signs of sickle cell anemia (SCA). Patient’s mother reports no family history; however, paternal aunt passed away at an early age. Ask What are the screen types for SCA, as well as, the other types of genetic anemias and how to differentiate between them? Access This article covers the insights into HbF gene regulation. 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